Product Details

METHOXSALEN

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.

Indication

For the treatment of psoriasis and vitiligo

Associated Conditions

• Idiopathic Vitiligo
• Refractory peripheral cutaneous T-cell lymphoma
• Severe Psoriasis

Pharmacodynamics

Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Mechanism of action

After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

SOURCE: DRUGBANK