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ABEN SUSP.

ABEN SUSP.
(1)

Composition:

ALBENDAZOLE-200MG/5ML-EACH PH/10ML

Group Name:

ANTI-HELMINTHIC DRUGS

Manufacturer:

NEPAL PHARMACEUTICAL LAB LTD.

Rs 16.74 / PH
Rs 18.00 7% off

Product Details

Class: Anthelmintic, Benzimidazole

Pharmacology

Mechanism of Action : Albendazole is a anthelmintic that causes parasitic death by binding to colchine-sensitive site of beta tubulin inhibiting their polymerization into microtubles.

Pharmacokinetics:

Absorption: <5%; may increase up to 4-5 times with a fatty meal

Distribution: Well inside hydatid cysts & CSF

Protein Bound: 70%

Metabolism: Hepatic; extensive first-pass effect; pathways include rapid sulfoxidation (major), hydrolysis, & oxidation

Half-life: 8-12 hr

Peak Plasma Time: 2-5 hr

Excretion: urine (<1% as active metabolite); feces

Dosage Forms & Strengths

tablet 200mg

  • Neurocysticercosis (Taenia Solium Tapeworm)

>60 kg: 400 mg PO BID x 8-30 days

<60 kg: 15 mg/kg/day divided BID PO x 8-30 days; not to exceed 800 mg/day 

  • Hydatid (Echinococcus Tapeworm)

>60 kg: 400 mg PO BID x 28 days, THEN 14 drug-free days x 3 cycles

<60 kg: 15 mg/kg/day divided BID PO, no more than 800 mg/day x 28 days, THEN 14 drug-free days x 3 cycles 

  • Ancylostoma, Ascariasis, Hookworm, Trichostrongylus

400 mg PO once

  • Capillariasis

400 mg PO qDay x10 days

  • Larva Migrans, Cutaneous & Trichuriasis

400 mg PO qDay x 3 days

  • Larva Migrans, Visceral

400 mg PO BID x 5 days

  • Enterobius (Pinworm)

400 mg PO once, repeat in 2 weeks

  • Fluke (Clonorchis Sinensis)

10 mg/kg PO qDay x7 days

  • Gnathostomiasis, Microsporidiosis

400 mg BID x 21 days

Administration :

  •     Administer with food.

  •     Oral tablets may be crushed or chewed and swallowed with water.

Monitor:

  •      Fecal specimens; 3 weeks after treatment.

  •      CBC (at the beginning of each treatment cycle and every 2 weeks during treatment.

  •       LFTs (transaminases)

Adverse Effects

>10%

Headache

  • Neurocysticercosis (11%)

  • Hydatid disease (1.3%)

Abnormal LFT

  • Hydatid disease (15.6%)

  • Neurocysticercosis (<1%)

1-10%

Abdominal pain

  • Hydatid disease (6%)

Nausea/vomiting

  • Hydatid disease (3.7%)

  • Neurocysticercosis (6.2%)

Dizziness/vertigo

  • Hydatid disease (1.2%)

  • Neurocysticercosis (<1%)

Increased intracranial pressure

  • Neurocysticercosis (1%)

Meningeal signs

  • Neurocysticercosis (1%)

Alopecia (reversible)

  • Hydatid disease (1.6%)

  • Neurocysticercosis (<1%)

Fever

  • Hydatid disease (1%)

    <1% (selected)

    Rash

    Urticaria

    Agranulocytosis

    Aplastic anemia

    Bone marrow suppression

    Granulocytopenia

    Pancytopenia

    Thrombocytopenia

    Hepatitis

    Acute liver failure

    Acute renal failure

Clinical Teaching:

  • Advice female patient to avoid pregency during treatment and for one month after discontinuation.

  • Warm patient to report symptoms of acute liver failure or hepatitis.

  • Side effect may include; abdominal pain, nausea, vomiting, alopecia, fever, dizziness, headache, or vertigo.

  • Instruct patient to take drug with food  

SOURCE : MEDSCAPE

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