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ADENOSINE INJ. *NOT USE*
ADENOSINE-3MG/ML-2ML
ANTIARRYTHMIC DRUGS
TROIKAA PHARMACEUTICAL
Product Details
Adenosine
A to Z Drug Facts
Adenosine
Action
Indications
Contraindications
Route/Dosage
Interactions
Lab Test Interferences
Adverse Reactions
PrecautionsPatient Care Considerations
Administration/Storage
Assessment/Interventions
Patient/Family Education
(ah-DEN-oh-seen)Adenocard, AdenoscanClass: Antiarrhythmic
Action Slows conduction through atrioventricular (AV) node; can interrupt reentry pathways through AV node and restore normal sinus rhythm.
Indications Conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with Wolff-Parkinson-White syndrome. Unlabeled use (s): Noninvasive assessment of patients with suspected coronary artery disease in conjunction with thallium tomography. Used with BCNU for treatment of brain tumors.
Contraindications Second- or third-degree AV block or sick sinus syndrome (except in patients with functioning artificial pacemaker); atrial flutter; atrial fibrillation; ventricular tachycardia.
Route/Dosage
ADULTS: Initial dose: IV 6 mg as rapid IV bolus (over 1 to 2 sec). REPEAT ADMINISTRATION: If first dose does not eliminate PSVT within 1 to 2 min, give 12 mg as rapid IV bolus; 12 mg dose may be repeated a second time if necessary. Doses > 12 mg are not recommended.
Interactions
Caffeine, theophylline: Antagonize effects of adenosine; larger doses of adenosine may be needed. Carbamazepine: May produce higher degrees of heart block. Dipyridamole: Potentiates effects of adenosine; smaller doses may be adequate.
Lab Test Interferences None well documented.
Adverse Reactions
CV: Facial flushing; headache; chest pain; hypotension. CNS: Lightheadedness, dizziness, tingling in arms; numbness. GI: Nausea. RESP: Dyspnea; shortness of breath; chest pressure.
Precautions
Pregnancy: Category C. Lactation: Undetermined. Arrhythmias: At time of conversion to normal sinus rhythm, new arrhythmias may appear on ECG; these are usually self-limiting. Asthma: Adenosine may cause bronchoconstriction. Heart block: Drug may produce short-lasting heart block. Patients in whom high-level heart block (eg, third-degree) develops after one dose should not receive repeat doses.
PATIENT CARE CONSIDERATIONS
Administration/Storage
- Administer by rapid IV bolus only.
- Administer either directly into vein or, if given into IV line, in most proximal IV line and follow with rapid saline solution flush.
- Do not administer if solution is cloudy or if sediment is present.
- Discard unused portion.
- Store at room temperature.
- Do not refrigerate because crystallization may occur. If crystallization has occurred, dissolve crystals by warming to room temperature.
Assessment/Interventions
- Obtain patient history, including drug history and any known allergies or asthma.
- Monitor BP and cardiac rhythm during and after administration.
- Monitor for transient asystole, which may develop during administration.
Patient/Family Education
- Inform patient to report the following symptoms to physician: Facial flushing, headache, shortness of breath, chest pressure, lightheadedness, dizziness, tingling in arms, numbness or nausea.
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Copyright © 2003 Facts and Comparisons
David S. Tatro
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