Product Details

Generic name: Calcium Carbonate and Vitamin D3

Category: Calcium supplementation

MECHANISM OF ACTION:

Calcium and Phosphorous are the two major components of bone. They are important in the metabolism of cells in the body and bone, therefore functions as a storage reservoir. Vitamin D is essential for promoting absorption & utilization of Calcium & Phosphate and for normal calcification of bone. It regulates serum Calcium concentration – a homeostatic mechanism. It stimulates Calcium & Phosphate absorption from small intestine and mobilize calcium from bone. Cholecalciferol is transferred to the liver & converted into Calcifediol (25 - Hydroxycholecalciferol) which then is transferred to kidneys & converted to Calcitriol (1, 25 – Dihydroxycholecalciferol).Calcitriol appears to act by: Increasing absorption of Calcium from the intestine; Regulates the transfer of Calcium ion from bone & re-absorption from distal renal tubule, Ionized Plasma Calcium level regulates the secretion of PTH. Therefore, Vit. D is included to increase Calcium absorption in Calcium Supplement for hypoparathyroidism.

INDICATION:

• Hypocalcemia
• Osteomalacia
• Rickets
• Chronic renal failure
• Osteoporosis
• Hyperkalemia
• Hypoparathroidism

PHARMACOKINETICS:

Absorption: Readily absorbed from small intestine (proximal & distal) Cholecalciferol may be absorbed more readily.

• Half-life ( Calcitriol): 3-6 hrs.
• Onset of action: 2-6 hrs.
• Duration of action: 3-5 days

Elimination: Biliary/renal

DOSAGE:

• Calvit Tablet: 1 tablet 2-3 times daily with meals or as directed by the Physician

PRECAUTIONS:

• Pregnancy
• Chronic Vit. D

Toxicity Maternal Hypercalcemia may cause increase sensitivity suppression of Parathyroid Hormone (PTH) function and Mental retardation in infants.

CONTRAINDICATIONS:

• Hypercalcemia patients
• Hypervitaminosis D
• Renal osteodystrophy with hyperphosphatemias
• Hypersensitivity effects of Vit. D
• Breast feeding women – can cause hypercalcemia in infants.

DRUGS INTERACTION:

• Calcium – containing preparation in high doses
• Diuretics: Thiazide
• Mineral Oils (reduce intestinal absorption)
• Digitalis (arrhythmia, hypercalcemia may potentiate Digitalis)
• Ca-tetracycline complexes formation.

OVERDOSE

• Constipation in Children & Adolescence
• Loss of appetite
• Metallic taste
• Frequent urination
• Muscle Pain
• Bone Pain