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FUBIOTIC CREAM-15M
FUSIDIC ACID-2% W/W
TOPICAL ANTIBIOTICS
CTL PHARMACEUTICALS- PHARMA "A" DIV
Product Details
FUSIDIC ACID
An antibiotic isolated from the fermentation broth of Fusidium coccineum. It acts by inhibiting translocation during protein synthesis.
Indication
For the treatment of bacterial infections.
Associated Conditions
- Conjunctivitis, Bacterial
- Mild Atopic dermatitis
- Mild Dermatitis caused by Staphylococcus aureusis
- Moderate Atopic dermatitis
- Moderate Dermatitis caused by Staphylococcus aureusis
Pharmacodynamics
Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.
Mechanism of action
Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Absorption
Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Volume of distribution
Not Available
Protein binding
97 to 99%
Metabolism
Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.
SOURCE:DRUGBANK