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ARGIN GRANULES-5GRAM
(1X10SACH)
L-ARGININE.
DIETARY SUPPLEMENTS-AMINO ACIDS
FOURRTS
Product Details
L-ARGININE
CLASS:
- Amino Acid Supplement
- Parenteral Solution
Mechanism Of Action:
L-Arginine is a precursor of nitric oxide, which exhibits activity as a vasodilator, platelet-aggregation inhibitor and modulator of immunological processes and epithelial premeability. Arginine also stimulates the release of pituitary growth hormone presumably as a result of effects on thye hypothalamus.
Pharmacokinetics:
Absorption:
- Tmax, IV: 22 to 30 minutes
- Tmax, Oral: 90 minutes
- Bioavailability, Oral: approximately 20%
Metabolism:
- Liver; extensive
Excretion:
- Renal; biphasic
Elimination Half Life
- 1.2 to 2 hours
Dosing and Indications:
Adult Dosing: Growth hormone stimulation test
- 30g IV infusion over 30 minutes; Max total dose 30g
Pediatric Dosing: Growth hormone stimulation test
- 59kg or less; 0.5g/kg IV infusion over 30 minutes; Max total dose 30g
- 60kg or greater; 30g IV infusion over 30 minutes; Max total dose 30g
Indications:
FDA-Labeled Indications
- Growth hormone stimulation test
Non-FDA-Labeled Indications
- Endothelial dysfunction
- Essential hypertension
- Intermitted claudication
- Urine acidification test
Adverse Effects:
Common: Dermatologic: Flushing, Injection site reaction, Endocrine metabolic: Increased body temperature, GIT: Vomiting, Neurologic: Headache, numbness
Serious: Endocrione metabolic; Hyperkalemia
Source: Micromedex Drug Reference
Substitutes
Substitutes not found for ARGIN GRANULES-5GRAM