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HELMAPREN-400MG

HELMAPREN-400MG

Composition:

ALBENDAZOLE-400MG

Group Name:

ANTI-HELMINTHIC DRUGS

Manufacturer:

LOMUS PHARMACEUTICALS PVT LTD.

Rs 9.30 / TAB
Rs 10.00 7% off

Product Details

Pharmacology

Mechanism of Action : Causes degeneration of cytoplasmic microtubule in intestinal and tegmental cells of intestinal helminths

Pharmacokinetics

Absorption: <5%; may increase up to 4-5 times with a fatty meal

Distribution: Well inside hydatid cysts & CSF

Protein Bound: 70%

Metabolism: Hepatic; extensive first-pass effect; pathways include rapid sulfoxidation (major), hydrolysis, & oxidation

Half-life: 8-12 hr

Peak Plasma Time: 2-5 hr

Excretion: urine (<1% as active metabolite); feces

Dosage Forms & Strengths

tablet 200mg

  • Neurocysticercosis (Taenia Solium Tapeworm)

>60 kg: 400 mg PO BID x 8-30 days

<60 kg: 15 mg/kg/day divided BID PO x 8-30 days; not to exceed 800 mg/day 

  • Hydatid (Echinococcus Tapeworm)

>60 kg: 400 mg PO BID x 28 days, THEN 14 drug-free days x 3 cycles

<60 kg: 15 mg/kg/day divided BID PO, no more than 800 mg/day x 28 days, THEN 14 drug-free days x 3 cycles 

  • Ancylostoma, Ascariasis, Hookworm, Trichostrongylus

400 mg PO once

  • Capillariasis

400 mg PO qDay x10 days

  • Larva Migrans, Cutaneous & Trichuriasis

400 mg PO qDay x 3 days

  • Larva Migrans, Visceral

400 mg PO BID x 5 days

  • Enterobius (Pinworm)

400 mg PO once, repeat in 2 weeks

  • Fluke (Clonorchis Sinensis)

10 mg/kg PO qDay x7 days

  • Gnathostomiasis, Microsporidiosis

400 mg BID x 21 days

Administration : Take with food

Monitor: CBC, LFTs

Adverse Effects

>10%

Headache

  • Neurocysticercosis (11%)
  • Hydatid disease (1.3%)

Abnormal LFT

  • Hydatid disease (15.6%)
  • Neurocysticercosis (<1%)

1-10%

Abdominal pain

  • Hydatid disease (6%)

Nausea/vomiting

  • Hydatid disease (3.7%)
  • Neurocysticercosis (6.2%)

Dizziness/vertigo

  • Hydatid disease (1.2%)
  • Neurocysticercosis (<1%)

Increased intracranial pressure

  • Neurocysticercosis (1%)

Meningeal signs

  • Neurocysticercosis (1%)

Alopecia (reversible)

  • Hydatid disease (1.6%)
  • Neurocysticercosis (<1%)

Fever

  • Hydatid disease (1%)

    <1% (selected)

    Rash

    Urticaria

    Agranulocytosis

    Aplastic anemia

    Bone marrow suppression

    Granulocytopenia

    Pancytopenia

    Thrombocytopenia

    Hepatitis

    Acute liver failure

    Acute renal failure

  • SOURCE : MEDSCAPE

Substitutes
ABEN-400MG

ABEN-400MG 7% off

(1)

Manufacturer: NEPAL PHARMACEUTICAL LAB LTD.

Rs 9.30 / TAB
Rs 10.00
ADOZ-400MG

ADOZ-400MG 7% off

(1)

Manufacturer: OMNICA

Rs 9.30 / TAB
Rs 10.00
ALBENDOL-400

ALBENDOL-400 7% off

(1X6X5)

Manufacturer: MICRO LABS LIMITED

Rs 9.30 / TAB.
Rs 10.00
ALLENTIN-400MG

ALLENTIN-400MG 7% off

(1)

Manufacturer: DEURALI JANTA PHARMACEUTICALS LTD.

Rs 9.30 / TAB
Rs 10.00
ALMEX-400

ALMEX-400 7% off

(1X25)

Manufacturer: SQUARE PHARMACEUTICALS LTD

Rs 9.30 / TAB.
Rs 10.00
BEND-400MG

BEND-400MG 7% off

(1)

Manufacturer: GENETICA LABORATORY PVT.LTD.

Rs 9.30 / TAB
Rs 10.00
+977 9851149866 +977 9851149866 +977 9851149866

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